QUIZ (Fill In The Blanks)
Oxygen-saturated Blood Reduces Damaged Heart Tissue
Results of a clinical trial published this week in Circulation: Cardiovascular
Interventions demonstrate that an infusion of blood that is "supersaturated"
with oxygen (SS02) can reduce the amount of damaged heart 1) ___ immediately
following a life-threatening heart attack. "The benefit of this therapy
increased with the scope of the 2) ___ attack," said Gregg W. Stone, M.D., lead
author. The data show that heart muscle can be 3) ___ even after severe heart
attack. The AMIHOT-II study focused on patients having the most serious types of
heart attacks - those with anterior ST-segment elevation myocardial infarctions
(STEMIs) - and on patients treated within 6 hours. Of the 733,000 Americans who
suffer acute coronary syndromes (i.e. heart attack or chest pain) each year,
361,000 (almost half) have a STEMI, according to the American Heart Association.
When a large area of the heart is damaged, heart failure is more likely, and
catheter-based percutaneous coronary intervention is a procedure that can
effectively open blocked 4) ___ in STEMI patients, Dr. Stone said. In the trial,
the "supersaturated" 5) ___ was delivered via catheter directly to the area of
the heart muscle affected by the heart attack. The size of the "infarct zone,"
or the amount of damaged tissue, was significantly 6) ___ in the patients that
received the "supersaturated" oxygen. Data from the study show that the median
size of the "infarct zone" was 20% in the patients that received the
"supersaturated" blood and 26.5% in the control group. In addition, at 30 days
after the treatment a key safety measure -- the rates of major adverse cardiac
events - were not statistically different between the two groups.
ANSWERS: 1) muscle; 2) heart; 3) saved; 4) arteries; 5) oxygen; 6) reduced
Results of a clinical trial published this week in Circulation: Cardiovascular
Interventions demonstrate that an infusion of blood that is "supersaturated"
with oxygen (SS02) can reduce the amount of damaged heart muscle immediately
following a life-threatening heart attack. "The benefit of this therapy
increased with the scope of the heart attack," said Gregg W. Stone, M.D., lead
author. The data show that heart muscle can be saved even after severe heart
attack. The AMIHOT-II study focused on patients having the most serious types of
heart attacks - those with anterior ST-segment elevation myocardial infarctions
(STEMIs) - and on patients treated within 6 hours. Of the 733,000 Americans who
suffer acute coronary syndromes (i.e. heart attack or chest pain) each year,
361,000 (almost half) have a STEMI, according to the American Heart Association.
When a large area of the heart is damaged, heart failure is more likely, and
catheter-based percutaneous coronary intervention is a procedure that can
effectively open blocked arteries in STEMI patients, Dr. Stone said. In the
trial, the "supersaturated" oxygen was delivered via catheter directly to the
area of the heart muscle affected by the heart attack. The size of the "infarct
zone," or the amount of damaged tissue, was significantly reduced in the
patients that received the "supersaturated" oxygen. Data from the study show
that the median size of the "infarct zone" was 20% in the patients that received
the "supersaturated" blood and 26.5% in the control group. In addition, at 30
days after the treatment a key safety measure -- the rates of major adverse
cardiac events - were not statistically different between the two groups.
Source: OnTarget Newsletter 21-9-2009